Product Description
Methylation is a chemical process your cells run all day, and it supports energy production, heart health, and brain function, which matters when your training weeks add up. Thorne's Methylation Stack supports healthy methylation through Methyl-Guard Plus, along with magnesium and vitamin D3 for the rest of the routine.
Methyl donors for cellular energy, heart, and brain support – Methyl-Guard Plus combines trimethylglycine, 5-MTHF, and methylcobalamin with active forms of B2 and B6 to support methylation, cellular energy production, heart health, brain function, and mood.
Magnesium for your heart and muscles – Magnesium CitraMate provides two well-absorbed forms of magnesium to support over 600 enzymatic processes, healthy cardiac and lung function, bone density, and your muscles.
Vitamin D3 for bones, muscles, and immune support – Vitamin D-5,000 provides 5,000 IU of vitamin D3 to support strong bones, muscle strength, cardiovascular health, and immune function.
Methyl donors are nutrients that give your cells the methyl groups they use in methylation. Methyl-Guard Plus supplies trimethylglycine (also called betaine), folate as L-5-MTHF, vitamin B12 as methylcobalamin, and the active forms of B2 and B6. Magnesium CitraMate pairs magnesium malate with magnesium citrate, and vitamin D3 is cholecalciferol, the form your skin makes from sunlight.
How to Use Thorne Methylation Stack
Dose: Take 1 to 3 capsules of Methyl-Guard Plus daily, 1 capsule of Magnesium CitraMate one to three times daily, and 1 capsule of Vitamin D-5,000 daily.
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Thorne Methylation Stack FAQ's
Everything you need to know about Thorne Methylation Stack.



Take 1 to 3 capsules of Methyl-Guard Plus daily and 1 capsule of Magnesium CitraMate one to three times daily. Take 1 capsule of Vitamin D-5,000 daily.
A full 3-capsule serving gives you 1.8 g of trimethylglycine, 5 mg DFE of folate as L-5-MTHF and 3 mg of B12 as methylcobalamin. You also get 45 mg of active B6 and 90 mg of active B2.
Each capsule has 135 mg of magnesium from two forms, malate and citrate. It supports your muscles, your heart and more than 600 enzymatic processes.
Each capsule has 5,000 IU (125 mcg) of vitamin D3. It supports strong bones, muscle strength and immune function.