Product Description
Thorne Methyl-Guard Plus gives your body the full methylation support it needs to sustain energy production, protect cardiovascular health, and recover efficiently from hard training. Four active B vitamins — already converted into the forms your body can immediately use — work alongside 1.8g of betaine to keep your methylation cycle running at full capacity, even under high training loads.
Athletes with high training volume, plant-based or low-meat diets, known MTHFR variants, or anyone whose bloodwork has flagged low B12 can benefit from Thorne Methyl-Guard Plus. And if you have the MTHFR variant, most B supplements deliver far less than their label suggests. Methyl-Guard Plus delivers active forms that skip the conversion step entirely.
Immediate Absorption, No Conversion Needed – Methyl-Guard Plus delivers methylcobalamin B12, 5-MTHF folate, pyridoxal 5'-phosphate B6, and riboflavin 5'-phosphate B2 — all in active, tissue-ready forms. Your body uses them immediately, without the conversion step that standard B vitamins require and that many athletes' genetics can't complete efficiently.
Dual-Pathway Methylation Support – Each full serving provides 1.8g of betaine (trimethylglycine), a direct methyl donor that gives your body a second independent route to maintain healthy homocysteine levels and keep methylation-dependent processes — energy metabolism, neurotransmitter production, DNA repair — running under pressure.
Sustained Energy and Sharper Recovery – When your methylation cycle is running efficiently, your body produces energy more consistently, repairs muscle tissue faster, and clears metabolic waste between sessions. Athletes on Methyl-Guard Plus report a noticeable lift in energy baseline and recovery quality within two to four weeks of daily use.
How to Use Thorne Methyl-Guard Plus
Daily Dose: Take 1–3 capsules daily with a meal. For full methylation support, three capsules is one serving — spread across the day if you're starting out to build tolerance.
Timing: Take with food. Morning with breakfast is the most consistent approach and avoids the mild stimulating effect some athletes notice from high-dose methylcobalamin close to bedtime.
Pro Tip: New to active-form B vitamins? Start with one capsule and build up over a week. Sensitive individuals can feel the difference with high-dose methylcobalamin, so ease in.
- Gluten free
Supplement Facts
30 Servings
Serving Size: Three Capsules
Serving Per Container: 30
| Amount Per Serving | ||
|---|---|---|
| % Daily Value* | ||
| Riboflavin (as Riboflavin 5'-Phosphate Sodium) 90mg | ** | |
| Vitamin B6 (as Pyridoxal 5'-Phosphate) 45mg | ** | |
| Folate (3 mg as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 5mg DFE | ** | |
| Vitamin B12 (as Methylcobalamin) 3mg | ** | |
| Betaine Anhydrous (Trimethylglycine) 1.8g | ** | |
* Percent Daily Values are based on a 2,000 calorie diet. Your daily values may be higher or lower depending on your calorie needs.
** Daily Value (DV) not established
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Thorne Methyl-Guard Plus FAQ's
Everything you need to know about Thorne Methyl-Guard Plus.
It's a high-potency methylation support formula. Methylation is a process your body runs billions of times a day — it affects your energy, mood, heart health, brain function, and recovery. When it's working well, you barely notice. When it's not, everything feels harder. This formula gives your body the specific nutrients it needs to keep that process running efficiently.
Most B-vitamin supplements use cheap, synthetic forms your body has to convert before it can actually use them. Here's the problem — a significant portion of the population (estimates range from 40–60%) has an MTHFR gene variant that makes that conversion inefficient or impossible. Methyl-Guard Plus skips the conversion step entirely. Your body gets what it needs, immediately.
The Plus version has a higher dose of betaine (trimethylglycine), making it the stronger formula. If you have elevated homocysteine, a known MTHFR variation, or you're training at high volume and want more robust support, Plus is the one to reach for.
Athletes training hard, anyone who's been told they have an MTHFR gene variant, people dealing with low energy or brain fog that doesn't have an obvious cause, or anyone who wants to make sure their B vitamins are actually working. It's also commonly recommended by practitioners for cardiovascular and cognitive support.
A small number of people are sensitive to methyl donors and may notice increased anxiety or vivid dreams when starting. Starting low and building up handles this for most people. Take with food if your stomach is sensitive.