Product Description
Glycine is one of the most abundant amino acids in the human body — and one of the most underappreciated in sports nutrition. It acts as a primary inhibitory neurotransmitter in the brainstem and spinal cord, it's a direct precursor to creatine synthesis, it contributes to glutathione production and liver detoxification, and it's a foundational building block of collagen.
For endurance athletes carrying the accumulated stress of high training volume, glycine quietly addresses multiple recovery demands at once. Thorne Glycine delivers a clean, flexible dose of one of the body's most functionally versatile amino acids.
CNS Calm and Sleep Quality – Glycine is a primary inhibitory neurotransmitter in the brainstem and spinal cord, where it modulates motor activity and stress signaling. Taken before bed, it lowers core body temperature — a key trigger for sleep onset — and clinical research shows it improves sleep quality, reduces daytime fatigue, and supports memory retrieval in sleep-deprived individuals. Calming support without sedation or dependency.
Creatine Precursor — Supporting Your Body's Own Production – Creatine is synthesized from three amino acids: arginine, methionine, and glycine. Adequate glycine availability supports the natural creatine production pathway — particularly relevant for plant-based athletes whose dietary glycine from animal connective tissue is limited.
Connective Tissue Foundation – Glycine is the most abundant amino acid in collagen, constituting roughly one-third of its structure. For endurance athletes accumulating repetitive mechanical stress on tendons and joints over long training blocks, glycine provides the foundational substrate for collagen synthesis and connective tissue maintenance.
Glutathione and Liver Detox Support – Glycine participates directly in phase II liver detoxification and contributes to glutathione synthesis. At high training volumes, metabolic waste production accelerates — glycine helps keep the body's clearance pathways running at pace.
How to Use Thorne Glycine
Daily Dose: Take 2 capsules three times daily with food, or as recommended by your healthcare practitioner. At 1g per 2-capsule serving, this delivers up to 3g glycine daily — consistent with the doses used in sleep quality research.
For Sleep Support: Take one full serving (2 capsules) 30–60 minutes before bed. Glycine's core body temperature-lowering effect is most relevant in the pre-sleep window.
- Gluten free
Supplement Facts
125 Servings
Serving Size: Two Capsules
Serving Per Container: 125
| Amount Per Serving | ||
|---|---|---|
| % Daily Value* | ||
| Glycine 1g | ** | |
* Percent Daily Values are based on a 2,000 calorie diet. Your daily values may be higher or lower depending on your calorie needs.
** Daily Value (DV) not established
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Thorne Glycine FAQ's
Everything you need to know before getting started.
Glycine supports sleep through two mechanisms. First, it acts as an inhibitory neurotransmitter in the CNS — particularly in the brainstem and spinal cord — calming the nervous system and reducing the motor and stress signals that interfere with sleep onset. Second, glycine lowers core body temperature, which is a key physiological trigger that signals the body to transition into sleep. Clinical research has shown that glycine supplementation before bed improves subjective sleep quality, reduces time to fall asleep, and decreases daytime fatigue and sleepiness the following day.
Creatine is synthesized by the body from three amino acids — arginine, methionine, and glycine — primarily in the kidneys and liver. Glycine is the rate-limiting amino acid in this process for many individuals. Supplementing glycine supports the body's own creatine production pathway, which is relevant for athletes who rely on creatine for power output and recovery, and especially for plant-based athletes whose dietary intake from meat and connective tissue is low.
Glycine is the most abundant amino acid in collagen, making up roughly one-third of its structure. Collagen is the primary protein in tendons, ligaments, cartilage, and other connective tissues that absorb the mechanical stress of repetitive endurance training. Providing adequate glycine substrate supports the collagen synthesis that maintains connective tissue integrity over long training blocks — particularly relevant for athletes accumulating high weekly mileage or impact.
Yes. Glycine pairs naturally with several Thorne products. With Thorne Alpha-Lipoic Acid — both support glutathione production through different mechanisms. With Thorne Milk Thistle Phytosome — complementary liver detox support. With Thorne L-Lysine — lysine and glycine together provide the two most important amino acids for collagen synthesis. No known adverse interactions with any standard supplement stack.