Product Description
The gut is where performance nutrition either pays off or gets wasted. You can dial in your protein timing, take all the right supplements, and eat clean at every meal — but if your digestive system isn't producing enough of the right enzymes at the right stages, the nutrients in that food never fully reach your muscles.
Endurance athletes are especially vulnerable: high training volume suppresses digestive enzyme output, antacid overuse depletes stomach acid, and aging quietly slows production across the board. The result is incomplete digestion that shows up as bloating, gas, and the kind of fatigue that doesn't respond to more food or more rest.
Thorne Advanced Digestive Enzymes steps in at every stage of that process to make sure the nutrition you're eating is actually getting used.
Rebuild the Stomach Foundation – Betaine hydrochloride and L-glutamic acid hydrochloride work together to restore stomach acidity, while porcine-sourced pepsin activates in that acidic environment to begin protein breakdown. This upstream foundation determines everything downstream: adequate HCL triggers the release of pancreatic enzymes and bile, sterilizes ingested pathogens, and facilitates the absorption of key micronutrients including B12, folate, iron, and zinc.
Complete Macronutrient Breakdown – Pancreatin is the pancreas's contribution to digestion — a concentrated blend of amylase (carbohydrate digestion), lipase (fat digestion), and protease (protein digestion). When the stomach acid signal is adequate, the pancreas releases these enzymes into the small intestine. When it isn't, pancreatin production drops and macronutrient digestion becomes incomplete.
Unlock Your Fat-Soluble Nutrients – Bile emulsifies dietary fats and is the essential vehicle for absorbing fat-soluble vitamins A, D, E, and K, as well as CoQ10 and omega-3 fatty acids. Athletes who have had their gallbladder removed lose the bile reservoir entirely — but even those with an intact gallbladder can have compromised bile output from chronic low stomach acid. Ox bile concentrate in this formula directly fills that gap, enabling full absorption of the fat-soluble micronutrients your body depends on for immunity, bone health, and cardiovascular function.
Together these five ingredients — betaine HCL, L-glutamic acid HCL, pepsin, pancreatin, and ox bile — replicate the complete digestive enzyme environment that your body produces from mouth to small intestine. This is broad-spectrum support, not just an antacid or a single-enzyme product.
How to Use Thorne Advanced Digestive Enzymes
With Every Meal: Take 1–2 capsules with each meal, or as recommended by your healthcare practitioner. The capsules work during active digestion — taking them at the start of a meal is ideal.
Adjust by Meal Size and Composition: Larger meals — especially those high in protein or fat — may benefit from 2 capsules. Lighter meals may need only 1. Let your digestive response guide your dose.
Pro Tip: Do not open the capsule or remove the powder — betaine HCL and L-glutamic acid HCL are irritating to the mouth and esophagus. Always swallow whole.
- Gluten free
Supplement Facts
90 servings
Serving Size: Two Capsules
Serving Per Container: 90
| Amount Per Serving | ||
|---|---|---|
| % Daily Value* | ||
| Betaine Hydrochloride 480mg | ** | |
| L-Glutamic Acid Hydrochloride 480mg | ** | |
| Pancreatin (Porcine) 140mg | ** | |
| Ox Bile concentrate 80mg | ** | |
| Pepsin (Porcine) 70mg | ** | |
* Percent Daily Values are based on a 2,000 calorie diet. Your daily values may be higher or lower depending on your calorie needs.
** Daily Value (DV) not established
Always Happy Promise: Don't like a product? Tell us within 30 days of receipt and we'll make it right and make you happy. Here at The Feed, we want you to love your experience and the sports nutrition products you purchase. If, for any reason, you are not satisfied with your nutrition specific purchase, tell us.
We do not accept returns on food items that have been opened, but we will issue a store credit if you are unsatisfied. In the event of a return, you must first contact us before sending back a return shipment.
Consumable products over $40 receive a 50% store credit. This includes specialty nutrition products such as ketones or supplements/vitamins.
Thorne Advanced Digestive Enzymes FAQ's
Everything you need to know before getting started.
Heavy training creates chronic physiological stress that suppresses digestive enzyme production. High-volume athletes eating large amounts of protein and carbohydrates put enormous demand on a digestive system that may be running below capacity. The result: incomplete protein digestion (less amino acid availability for recovery), poor fat-soluble vitamin absorption (vitamins A, D, E, K — critical for immunity and bone health), and the GI discomfort that plagues endurance athletes during training and racing. Digestive enzyme support ensures the nutrition you're already eating is fully extracted and absorbed.
Athletes who have had their gallbladder removed — which eliminates the bile reservoir and significantly impairs fat digestion and fat-soluble vitamin absorption. But ox bile is also relevant for anyone with chronically low stomach acid (which normally triggers bile release), heavy fat intake around training, or poor absorption of fat-soluble vitamins despite supplementation. If you're taking omega-3s, CoQ10, or vitamins A, D, E, or K and not getting expected results, inadequate bile output may be why.
Many digestive enzyme supplements dilute their pepsin and pancreatin with lactose as a carrier, which reduces the effective enzyme concentration per capsule and adds a potential problem for lactose-sensitive individuals. Thorne's formula uses undiluted, lactose-free forms — the same concentration per capsule, without the dilution compromise.
Yes. Like Betaine HCL & Pepsin, Advanced Digestive Enzymes should not be used concurrently with H2-blocking drugs or proton pump inhibitors (PPIs) — these medications are designed to suppress stomach acid, which directly conflicts with the HCL component of this formula. Do not use with active peptic or duodenal ulcers. Consult your healthcare practitioner if you're on any acid-related medications.