Pure Encapsulations Reduced Glutathione

Every hard effort floods your cells with reactive oxygen species — the metabolic byproducts of pushing your body to produce more energy. Your primary defense against that oxidative damage? Glutathione.

It's the most abundant antioxidant in nearly every cell of your body, and it does the heavy lifting when it comes to neutralizing free radicals, repairing DNA, recycling other antioxidants like vitamin C, and detoxifying harmful compounds through your liver. The problem is that prolonged, intense exercise actively depletes your glutathione stores, leaving your cells vulnerable right when they need protection most.

Your Body's Most Important Antioxidant

Pure Encapsulations Reduced Glutathione delivers 100mg of Setria® glutathione per capsule — a clinically studied, bioavailable form that has been shown to increase glutathione levels in the blood, red blood cells, and immune cells with consistent daily use.

Neutralizes Exercise-Induced Oxidative Damage – Hard training increases oxygen consumption, which ramps up free radical production in your muscles and throughout your body. Glutathione is your frontline defense, directly scavenging those free radicals and protecting cell membranes from the lipid peroxidation that leads to muscle damage, inflammation, and slower recovery.

Supports Faster Recovery and Reduced Muscle Fatigue – Research shows that oral glutathione supplementation suppressed markers of muscle damage (like creatine kinase) after exercise and supported aerobic metabolism in skeletal muscles. A double-blind crossover study in healthy men found that two weeks of glutathione supplementation helped reduce fatigue during and after cycling exercise, partly by supporting mitochondrial energy production and reducing muscle acidosis.

Boosts Immune Function When Training Hits Hard – A six-month clinical trial showed that Setria® glutathione at 1,000mg/day more than doubled natural killer cell activity — a critical marker of immune defense. For athletes who lose training days to illness after hard blocks, maintaining glutathione levels helps keep your immune system strong when it's most suppressed.

Glutathione also enhances the antioxidant activity of vitamin C, supports amino acid transport, and promotes liver detoxification — clearing the metabolic waste products that accumulate during high-volume training. It's not just an antioxidant, it's the antioxidant that makes your other antioxidants work better.

How to Use Pure Encapsulations Reduced Glutathione

Daily dose: Take 1 capsule, 1–2 times daily, between meals.

Timing: Take on an empty stomach between meals for best absorption. Splitting into morning and evening doses helps maintain consistent levels.

Pro tip: Pair with NAC (N-acetyl cysteine) and vitamin C to maximize your body's glutathione production and recycling. Quercetin also supports glutathione levels, making it a natural complement in an antioxidant stack.

Endurance athletes, masters-age competitors, and anyone logging high-volume training weeks benefit from maintaining glutathione levels. It's the foundational antioxidant that supports everything downstream, from recovery to immunity to cellular energy production.